What is Zymurine Tablet prescribed for? How does it work?

Zymurine Tablet is an immunosuppressant which means that it acts by suppressing the immune defense system of the body. Your immune defense system helps to protect you against infections. However, sometimes your immune defense system can become overactive and can cause illness. Zymurine Tablet is used in combination with other medicines to treat the conditions caused due to this abnormal activity of the immune system. It is used to prevent rejection of transplanted organs, like the kidney, heart or liver. It is also used to treat chronic active hepatitis, severe rheumatoid arthritis, systemic lupus erythematosus (SLE), idiopathic thrombocytopenic purpura and acquired hemolytic anemia. It is also used to treat severe cases of specified skin diseases (pemphigus vulgaris, dermatomyositis, polyarteritis nodosa, pyoderma gangrenosa), especially when corticosteroids cannot be used.

How long does Zymurine Tablet take to start working?

It may take about 3 to 12 weeks before you see any benefits. Continue the medication even if you do not notice any benefits. Talk to your doctor if you face any issues.

What happens if I forget to take Zymurine Tablet?

If you miss a dose of Zymurine Tablet, take it as soon as you remember. However, skip the missed dose if it is time for your next dose. Do not take a double dose to compensate for the missed dose. inform your doctor if the dose is frequently missed.

How long do I need to take Zymurine Tablet?

The duration varies from person to person as it is prescribed depending upon the patient’s medical condition.

Is breastfeeding safe during Zymurine Tablet treatment?

No, breastfeeding should be avoided, while on Zymurine Tablet, since it may harm the baby and cause serious side effects.

I have just started taking Zymurine Tablet. What are the long-term side effects? Is there anything I should be looking out for?

Being an immunosuppressant, Zymurine Tablet can increase the chances of severe infections, decrease in blood cell counts, and malignancy. You should inform your doctor immediately if you notice any infection or fever, unexpected bruising or bleeding, black tarry stools or blood in the urine or stools. Let your doctor know if you notice any new skin sore or lump, new marks on skin or any change in the marks which were previously present.

Do I need any special tests while I am on Zymurine Tablet?

Zymurine Tablet reduces the production of blood cells making you more vulnerable to infections and can sometimes affect the liver. These side effects can be monitored by regular blood tests. Therefore, during the first 8 weeks of the treatment your doctor may recommend weekly blood tests to monitor complete blood counts, including platelet counts. The frequency can later be reduced to monthly or at least once in 3 months time.

Can Zymurine Tablet cause cancer?

Zymurine Tablet may increase the chance of developing certain cancers like skin cancer, cancer of the lymph system (lymphoma), cancer of soft tissues (sarcomas), and cervical cancer. To prevent the risk of skin cancer, avoid prolonged exposure to sunlight and wear protective clothing, sunglasses, and sunscreen. Tell your doctor immediately if you notice any changes in your skin or any lumps or masses anywhere on your body.

Can cyclosporine and Zymurine Tablet be taken together?

Yes, you can take cyclosporine and Zymurine Tablet together as they do not interfere with each other’s working. However, you must take the two medicines strictly as per your doctor’s advice.

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Azathioprine (50mg)

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Zymurine Tablet belongs to a group of medicines called immunosuppressants. It is used with other medicines to prevent your body from rejecting an organ (such as a kidney, heart, or liver) after a transplant. It is also used in the treatment of rheumatoid arthritis.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Varun Gupta, MD Pharmacology, MBBS,
Last updated on 12 Nov 2024 | 01:09 AM (IST)

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General Information

Contains

Azathioprine (50mg)

Marketer

Zydus Cadila

Storage

Store below 30°C

The content is shown in English

Product introduction

Zymurine Tablet works by weakening the body’s immune system, so it does not attack the new organ. The amount of medicine to be taken and how often you need to take it will depend on the type of transplant you have. Follow your doctor’s instructions on this. You should take it along with food. Take the medicine regularly to get the most benefit and keep taking it even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ.

It has many potential side effects. The most common are loss of appetite, nausea, and increased risk of bleeding. Because it suppresses your immune system, you may catch infections easily. There’s also an increased risk of developing some cancers for this reason. You should ask your doctor about side effects that may need urgent medical attention.

Zymurine Tablet can cause birth defects and miscarriages so do not take it if you are pregnant, planning to become pregnant, or breastfeeding. You should talk to your doctor before taking this medicine if you have any signs of infection or if you have any unexpected bruising or bleeding. Your doctor also needs to know what other medicines you are taking as there are many which interact with this medicine and affect the way it works. You will have regular tests to check for any changes in the number of your blood cells.

Uses of Zymurine Tablet

Benefits of Zymurine Tablet

Prevention of organ rejection in transplant patients
Zymurine Tablet is an immunosuppressive agent that lowers your immune response and reduces the chance of your body attacking the transplanted organ. Organ rejection happens when your immune system treats the new organ as an invader and attacks it. This medicine may be used in combination with other medicines to suppress the immune system and help your body accept the new organ.

Treatment of Rheumatoid arthritis
Zymurine Tablet works by blocking the action of some chemicals which cause inflammation. It can help reduce pain, stiffness, and swelling in your joints and slow down the progression of bone and joint damage. This will help you do normal daily activities more easily and thus improve your quality of life. This medicine should be taken at the same time each day to get maximum benefits. Keep taking it even if you feel well because it is preventing future harm as well as improving your symptoms.

Side effects of Zymurine Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zymurine

Decreased white blood cell count
Increased bleeding tendency
Nausea
Infection
Loss of appetite

How to use Zymurine Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zymurine Tablet is to be taken with food.

How Zymurine Tablet works

Zymurine Tablet is an immunosuppressant. It reduces the action of body's own defense system (the immune system) and prevents rejection of the transplanted organ. It also blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain joint diseases.

All substitutes for Zymurine Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Your doctor has prescribed Zymurine Tablet to stop the body from rejecting a transplanted organ (e.g. kidney, heart or liver).
Zymurine Tablet also relieves joint pain and inflammation in rheumatoid arthritis.
You may have to take additional medications along with Zymurine Tablet for better relief of symptoms.
Avoid contact with people who have cold, flu or other contagious illness. Notify your doctor if you have any signs of infection such as a fever or sore throat.
Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Zymurine Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Zymurine Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Zymurine Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Zymurine Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

CAUTION

Zymurine Tablet should be used with caution in patients with kidney disease. Dose adjustment of Zymurine Tablet may be needed. Please consult your doctor.
Use of Zymurine Tablet is not recommended in patients with serious kidney disease.

Liver

CAUTION

Zymurine Tablet should be used with caution in patients with liver disease. Dose adjustment of Zymurine Tablet may be needed. Please consult your doctor.
Use of Zymurine Tablet is not recommended in patients with severe liver disease. Regular monitoring of liver function tests is advisable while you are taking this medicine.

Fact Box

Chemical Class

Nucleoside Analog, and Purines

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Immunosuppressant- Purine analogs

Related lab tests

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1013-14.
Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 629-30.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 113-15.
Azathioprine. San Diego, California: Prometheus Laboratories Inc.; 2014. [Accessed 06 Apr. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:
Oxford Radcliffe Hospitals: NHS Trust. Azathioprine - General Information; 2012. [Accessed 17 Jun. 2019]. (online) Available from:
Azathioprine [Product Information]. Parsippany, NJ: Ascend Laboratories, LLC; 2021. [Accessed 09 Jun, 2023] (online) Available from:
Mohammadi O, Kassim TA. Azathioprine. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 09 Jun, 2023] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zydus Cadila
Address: Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Zymurine Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Why we need a prescription?

Name: Zydus Cadila
Address: Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India