Diabetes Package near me in Chandigarh

Cholesterol is essential for life, as it is required by the body to work properly. It plays a role in the formation of cell membranes in all organs and tissues in the body. It is associated with the formation of hormones which are important for development, growth, and reproduction. It forms bile acids, which help to absorb nutrients from food. 

In the blood, a small amount of cholesterol circulates in the form of lipoproteins which contains protein, cholesterol, triglyceride, and phospholipid molecules. These are classified according to their density into HDL (high-density lipoproteins), LDL (low-density lipoproteins), and VLDL (very low-density lipoproteins). HDL cholesterol is also known as good cholesterol, as it carries excess cholesterol away for disposal while LDL cholesterol is also known as bad cholesterol, as it deposits cholesterol in tissues and organs. 

It is important to maintain and monitor the levels of cholesterol for a healthy lifestyle. The source of cholesterol is diet as well. If a person is taking too much of cholesterol-rich foods, it can cause a rise in levels of cholesterol in the blood. The amount of cholesterol which is not required by the body starts to deposit in the form of plaques on the walls of blood vessels. These plaques can narrow or block the blood vessels opening which can lead to the hardening of arteries known as atherosclerosis. Also, with an increase in cholesterol levels, there is an increased risk of various conditions such as heart disease and stroke. 

Creatinine is a waste product which is produced by the muscles due to the breakdown of a compound called Creatine. During the cycle of energy production which is required to contract muscles, creatine is produced. Kidneys remove creatinine from the body by filtering it from the blood and then releasing it into the urine. This test measures the amount of creatinine in the blood.

The body produces creatine and creatinine at a relatively same rate. Since kidneys filter most of the creatinine from the blood and release it into the urine, the blood levels can be used as an indicator to know how well the kidneys are functioning. The amount of creatinine produced depends upon the size of the person as well as their muscle mass. That is why levels of creatinine are higher in men as compared to women and children.

Triglycerides test measures the levels of triglycerides in the blood.

Triglycerides are a type of body fat (lipid). Chemically, triglycerides consist of three ("tri-") molecules of fatty acid combined with a molecule of the alcohol glycerol ("-glyceride").

High levels of triglycerides in the blood have been linked to atherosclerosis which increases the risk of heart disease (Coronary Artery Disease), peripheral artery disease, stroke and kidney disease. Atherosclerosis is a disease in which plaque (made up of fat, cholesterol, calcium, and other substances) builds up inside the arteries (blood vessels) resulting in narrowing of the lumen. This restricts the flow of blood to the organs and other parts of the body. Signs and symptoms of atherosclerosis usually do not appear until severe or total blockage of the artery (blood vessel). Therefore, most people are not aware of atherosclerosis until they have a medical emergency, such as a heart attack or stroke.

Increased levels of triglycerides may also be seen in Metabolic syndrome (cluster of metabolic risk factors for cardiovascular disease, type 2 diabetes and stroke). Very high triglyceride levels can also cause inflammation of the pancreas (pancreatitis).

Triglycerides test is usually done as a part of lipid profile which includes other tests like cholesterol, HDL (High-density lipoprotein), LDL (Low-density lipoprotein), VLDL (Very low-density lipoprotein) also.

Urea is a byproduct of protein metabolism. Proteins consumed in the diet are digested and converted into amino acids, which are utilized by the body. This metabolic process creates toxic byproduct ammonia. This byproduct is rapidly converted by the liver to form urea, which is less toxic and is transported relatively safely in blood. Following this, urea is transported by the blood to the kidneys. The kidneys then filter it out of the blood and excrete it out of the body in a solution called urine. This process continues and the body keeps producing and excreting urea, hence maintaining a low and steady level of urea in the blood.

The BUN test measures the amount of urea present in the urea. The levels of BUN test in the blood are affected due to impairment of kidney function, or due to large scale liver conditions. Primarily, BUN Test results are used to evaluate kidney functioning. Results are often interpreted together with results of Creatinine Tests that measure the levels of another metabolic waste (creatinine), which is also excreted in the urine.

The Uric acid test measures the levels of uric acid in the blood. Uric acid is a nitrogenous compound produced by the metabolic breakdown of purine. Purines are nitrogenous bases in DNA forming parts of the structural framework of the cells. Breakdown of purines occurs when cells become old and die, forming uric acid. Uric acid is also formed from the metabolic breakdown of some types of food like red meat, seafood, beans, etc.

Most of the uric acid in the blood is filtered and eliminated by the kidneys and a small remaining amount in the stool. The concentration of uric acid in the blood can increase due to overproduction of uric acid or improper elimination of uric acid, and this condition is called Hyperuricemia. Hyperuricemia can also be caused due to cancer treatment by chemotherapy or radiotherapy. These treatment methods kill the cancer cells, which may leak the uric acid into the blood.

Excess uric acid can form crystals in the synovial fluid between the joints causing inflammation and pain. This condition is called gout and can severely damage the joints if left untreated. The Uric Acid Test can indicate the presence of gout, or risk of formation of gout. However, it is not a definitive test for gout. Confirmatory test for gout is performed by analysis of synovial fluid (joint fluid) for monosodium urate crystals. Chronic Hyperuricemia can cause the formation of tophi, which are hard lumpy deposits of uric acid crystals formed under the skin, in the joints, and at the top of the ears. Tophi cause severe damage to the joints and may compress nerves causing chronic pain and disfigurement. The excess uric acid may also deposit and crystallize in the kidneys causing kidney stones and acute renal failure.

Glycosylated Hemoglobin Test measures the percentage of glycosylated hemoglobin in blood which reflects the average blood glucose over a period of past two to three months (8 - 12 weeks).

Hemoglobin is the protein found in Red Blood Cells and is responsible for transporting oxygen. Of the different types of hemoglobin, Hemoglobin A is predominant. With the elevation of blood sugar levels, some glucose binds spontaneously to Hemoglobin A (this binding is called Glycosylation or Glycation) and remains bound for the complete lifetime of the RBC, which is 120 days normally. Higher the level of glucose in the blood, greater is the amount of it binding to Hemoglobin A. Hemoglobin A1c is the dominant form of Glycated Hemoglobin. As RBCs die and are replaced, Hemoglobin A1c is cleared and slowly replaced with non-glycosylated hemoglobin. Measurement of HbA1c level over a period of time gives an indication of the level of glucose in the blood over the specified period of time. This helps in the diagnosis of Diabetes and is useful for monitoring the effectiveness of measures taken to reduce blood sugar levels.

Glucose - Fasting Blood Test is done to measure the levels of glucose in blood during period of fasting.

Glucose is the main source of energy for body. Carbohydrates consumed in the diet are broken down in the body to glucose, which is absorbed by the intestines and transported by the blood to various organs. The cells of these organs utilize the glucose to produce energy when required, and the excess is stored either as glycogen in the liver for short-term storage or in fat tissues as triglycerides for long-term storage. The uptake, utilization, and storage of glucose after it is absorbed in the intestines is facilitated by the hormone- insulin which is secreted by the pancreas. Insulin influences the transport of glucose to the organs like heart, brain, working muscles, etc. It also directs storage of excess glucose. The action of insulin reduces sugar levels in the blood.

After a meal, sugar levels increase in blood and insulin is secreted in response to reduce sugar levels until it becomes normal. If glucose levels fall too low in blood, another pancreatic hormone called glucagon is released, which directs the liver to convert stored glycogen into glucose and releases it into the blood. The insulin and glucagon hormones create a feedback mechanism to keep blood glucose levels within the normal range. Imbalance in their activity causes an excess or shortage of blood sugar.

Glucose - Fasting blood Test helps to determine if the body is able to utilize or store glucose efficiently. High levels of sugar in blood indicates diabetes or resistance to insulin. Type 1 Diabetes is caused when insulin is not produced or produced in very little quantity. Type 2 Diabetes is caused when insulin produced is not utilized effectively by the body. In both these cases, blood sugar level rises, while cells are deprived of nutrition.

The Blood Urea Nitrogen test measures the amount of urea nitrogen in the blood. Urea is a waste product which is formed in the liver. It is formed when protein is metabolized into amino acids. This leads to the production of ammonia which is further converted into urea which is a less toxic waste product. 

Both ammonia and urea have nitrogen as their component. The liver releases urea into the blood which is then carried out to the kidneys. Here, it is filtered out of the blood and then released into the urine. Since this is a continuous process, a small and stable amount of urea nitrogen always remains in the blood.

In the case of kidney or liver diseases, there is a change in the amount of urea present in the blood. If the liver produces urea in increased amounts or if there is any problem in the functioning of the kidneys, there can be difficulty in filtering out wastes of the blood which will lead to rising in urea concentrations in the blood. If due to liver damage or disease there is less production of urea, the concentration of BUN will fall.

The BUN test is done along with creatinine test to evaluate kidney function to diagnose kidney disease and to monitor patients undergoing treatment of kidney disease.