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Guaifenesin + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Phenylpropanolamine is a combination of four medicines: guaifenesin, chlorpheniramine, dextromethorphan and phenylpropanolamine which relieve cough. Guaifenesin is an expectorants which decreases the stickiness of mucus (phlegm) and helps in its removal from the airways. Chlorpheniramine is an antiallergic which relieves allergy symptoms like runny nose, watery eyes and sneezing. Dextromethorphan is a cough suppressant that relieves cough by reducing the activity of cough centre in the brain. Phenylpropanolamine is a decongestant which narrows the small blood vessels providing relief from congestion or stuffiness in the nose.