


Trima 300mg Tablet
Moclobemide (300mg)
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Trima 300mg Tablet helps treat depression. It reduces and gradually eliminates the symptoms of depression such as deep sadness, feelings of worthlessness, loss of interest in activities, sleep disturbances, tiredness, feelings of anxiety, and weight changes.
Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 12 Nov 2024 | 01:05 AM (IST)
Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 12 Nov 2024 | 01:05 AM (IST)
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General Information
The content is shown in English



Product introduction
Trima 300mg Tablet should be taken with food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. If you have missed any doses, take it as soon as you remember and finish the full course of treatment even if you feel better. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms.
Some common side effects of this medicine include nausea, vomiting, headache, fatigue, insomnia (difficulty sleeping), and dry mouth. Other side effects that may also be observed are constipation, restlessness, diarrhea, and agitation. However, these are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or worry you. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.
Before taking this medicine, please tell your doctor if you suffer from any liver problems or diabetes. If you have been taking this medicine for a long time, regular monitoring of blood and liver functions may be required. It is important to inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts. Pregnant and breastfeeding mothers should consult their doctor before taking this medicine.
Some common side effects of this medicine include nausea, vomiting, headache, fatigue, insomnia (difficulty sleeping), and dry mouth. Other side effects that may also be observed are constipation, restlessness, diarrhea, and agitation. However, these are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or worry you. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.
Before taking this medicine, please tell your doctor if you suffer from any liver problems or diabetes. If you have been taking this medicine for a long time, regular monitoring of blood and liver functions may be required. It is important to inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts. Pregnant and breastfeeding mothers should consult their doctor before taking this medicine.
Uses of Trima Tablet
Benefits of Trima Tablet
Depression
Trima 300mg Tablet helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. It helps you sleep better and increases your energy levels. This improves your mood, relieves anxiety, tension, prevents extreme mood changes, and helps you feel less agitated. You may experience fewer episodes of depression and low mood.
It can take several weeks for this medicine to work and you may still feel low during this time. It is likely that you will take this medicine for at least six months but possibly much longer. It needs to be taken regularly to work effectively. Do not stop taking it unless your doctor tells you to.
Trima 300mg Tablet helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. It helps you sleep better and increases your energy levels. This improves your mood, relieves anxiety, tension, prevents extreme mood changes, and helps you feel less agitated. You may experience fewer episodes of depression and low mood.
It can take several weeks for this medicine to work and you may still feel low during this time. It is likely that you will take this medicine for at least six months but possibly much longer. It needs to be taken regularly to work effectively. Do not stop taking it unless your doctor tells you to.
Side effects of Trima Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Trima
- Nausea
- Vomiting
- Headache
- Insomnia (difficulty in sleeping)
- Dizziness
- Dryness in mouth
- Constipation
- Restlessness
- Diarrhea
- Agitation
How to use Trima Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trima 300mg Tablet is to be taken with food.
Avoid Trima 300mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Avoid Trima 300mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
How Trima Tablet works
Trima 300mg Tablet increases the levels of chemical messengers in the brain that helps in regulating the mood and treat depression.
Quick tips
- Trima 300mg Tablet should be taken with food, preferably at the same time every day.
- Do not drive or do anything requiring concentration until you know how Trima 300mg Tablet affects you.
- As a precaution, foods high in tyramine (e.g., aged cheeses, air-dried meats, soy sauce, tap/draft beers and red wines) should be avoided when taking Trima 300mg Tablet, as it may cause an unsafe rise in your blood pressure.
- Inform your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Do not stop taking the medication suddenly without talking to your doctor.
Safety advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with Trima 300mg Tablet. Please consult your doctor.

Pregnancy
CONSULT YOUR DOCTOR
Trima 300mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding
SAFE IF PRESCRIBED
Trima 300mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving
SAFE
Trima 300mg Tablet does not usually affect your ability to drive.

Kidney
SAFE IF PRESCRIBED
Trima 300mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Trima 300mg Tablet is recommended.

Liver
CAUTION
Trima 300mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Trima 300mg Tablet may be needed. Please consult your doctor.
Interaction with drugs
Taking Trima with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening
Mephentermine (Injection Route)
Concurrent use may cause a severe or fatal increase in blood pressure.
Life-threatening
Methylphenidate (Oral Route)
Concurrent use may cause a severe or fatal increase in blood pressure.
Frequently asked questions
Trima 300mg Tablet is an antidepressant that is used to treat depression and improves your mood.
Trima 300mg Tablet may take from a few days to several weeks to be really effective. The length of the treatment will depend on how quickly your symptoms improve. Most antidepressants take time to work so don't be discouraged if you don't feel better right away.
Trima 300mg Tablet should be taken morning and evening at the end of your meal.
Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake, and sugarless candy may help.
No, Trima 300mg Tablet is not recommended for children since its safety is not established in this population.
Trima 300mg Tablet may cause eye pain, changes in vision, or swelling or redness in or around the eye. Seek immediate medical help if you notice such symptoms.
Trima 300mg Tablet may cause blurred vision or make some people drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires mental alertness and vision.
Yes, headache is one of the side effects of Trima 300mg Tablet. Take rest and drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor.
Yes, Trima 300mg Tablet may cause constipation. Try to eat a well-balanced diet with lots of fibre and drink plenty of water. Do not take any laxatives without consulting your doctor.
Nausea and vomiting are some of the common side effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty.
Yes, Trima 300mg Tablet may cause a feeling of light-headedness and faintness. Do not stand up too quickly and try to lie down when you see it coming on.
Fact Box
Chemical Class
Benzamides Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Mono-Amine Oxidase (MAO) inhibitors
References
- Stahl SM, editor. Moclobemide. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 447-52.
- Moclobemide. Hertfordshire, UK: Mylan Products Limited; 2009 [revised Feb. 2018]. [Accessed 25 Mar. 2019] (online) Available from:
- Drugs.com. Moclobemide. [Accessed 25 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Vendor Details
Country of origin: India
Lab tests offered by us
- Complete Blood Count
- Glucose - Fasting
- Thyroid profile Total
- Glycosylated Hemoglobin
- Glucose - Postprandial
- Lipid Profile
- Vitamin D (25-OH)
- Urine Routine & Microscopy
- Coronavirus Covid-19 Test (RT-PCR technique)
- Liver Function Test
- Kidney Function Test
- Thyroid Stimulating Hormone, Ultrasensitive
- Erythrocyte Sedimentation Rate
- Uric Acid
- Vitamin B12
- C- Reactive Protein Quantitative
- Urine Culture and Sensitivity
- Serum Electrolyte
- Calcium
- Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- Kidney Function Test with Electrolytes
- Cholesterol - Total
- Hemoglobin
- Complete Haemogram
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