Pazoci 400 Tablet is a protein kinase inhibitor used in the treatment of kidney cancer and soft tissue sarcoma.

Pazoci 400 Tablet should be taken in a dose as recommended by the doctor. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Doctor may advice for regular monitoring of your blood pressure as Pazoci 400 Tablet can cause high blood pressure.

Women who are undergoing treatment should use effective contraception method. It is important to avoid pregnancy during the treatment and for one month after completing the course of medicine. Diarrhea may occur as its side effect, so drink plenty of fluids. But, you must inform doctor if it does not stop. Weight loss may occur but you may consult dietitian or increase food portion to overcome this side effect. It may also cause change in color of hair, and abnormal skin pigmentation. However, if it bothers you than it is better to consult with doctor.

There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Uses of Pazoci Tablet

Benefits of Pazoci Tablet

In Kidney cancer

Pazoci 400 Tablet is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.

In Soft tissue sarcoma

Soft tissue sarcoma is a type of sarcoma that develops in tissues such as bone and muscles. Pazoci 400 Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Follow your doctor’s instructions carefully and let your doctor know if any of the side effects bother you.

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Side effects of Pazoci Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pazoci

Headache
Nausea
Vomiting
Musculoskeletal (bone, muscle or joint) pain
Fatigue
Change in color of hair
Diarrhea
High blood pressure
Decreased appetite
Weight loss
Taste change
Abnormal skin pigmentation
Hair discoloration
Tumor pain
Breathlessness

How to use Pazoci Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pazoci 400 Tablet is to be taken empty stomach.

How Pazoci Tablet works

Pazoci 400 Tablet is an anti-cancer medication. It works by binding and inhibiting the enzyme receptors (tyrosine kinase) that are responsible for the proliferation of the cancerous cells. It also restricts the growth of new blood vessels within the tumor. This is how it works against cancer.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Pazoci 400 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Pazoci 400 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Pazoci 400 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Pazoci 400 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Pazoci 400 Tablet is safe to use in patients with kidney disease. No dose adjustment of Pazoci 400 Tablet is recommended.

Liver

CAUTION

Pazoci 400 Tablet should be used with caution in patients with liver disease. Dose adjustment of Pazoci 400 Tablet may be needed. Please consult your doctor.
Use of Pazoci 400 Tablet is not advised in patients with moderate to severe liver disease.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Pazoci 400 Tablet

₹333.17/Tablet

Votrient 400mg Tablet

Glaxo SmithKline Pharmaceuticals Ltd

₹579/tablet

74% costlier

Pazliz 400 Tablet

Khandelwal Laboratories Pvt Ltd

₹336.67/tablet

1% costlier

Pazolee 400mg Tablet

Admac Pharma Ltd

₹530/tablet

59% costlier

Pazeqol 400 Tablet

Intas Pharmaceuticals Ltd

₹333.17/tablet

same price

Pazocam 400mg Tablet

Medicamen Biotech Ltd

₹150/tablet

55% cheaper

View all substitutes

Fact Box

Chemical Class

Alkyldiarylamines Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine kinase inhibitors

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FAQs

Is Pazoci 400 Tablet a chemotherapy medicine?

Pazoci 400 Tablet is not a conventional chemotherapy medicine. It belongs to a class of medicine called a protein kinase inhibitor. Pazoci 400 Tablet works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.

How should I take Pazoci 400 Tablet?

Pazoci 400 Tablet should be taken orally by mouth once a day or as directed by your doctor. Swallow the tablets whole with water, do not break or crush the tablets. This affects the way the medicine is absorbed and may increase the chance of side effects.

Can Pazoci 400 Tablet be taken with food?

Pazoci 400 Tablet should be taken on an empty stomach, at least 1 hour before or 2 hours after food. If it is taken with food, the dosage may need to be increased. Doing this will in turn cause more side effects.

How will I know if Pazoci 400 Tablet is helping me?

The duration for which you have to continue taking Pazoci 400 Tablet varies from person to person. The doctor monitors you closely and will be able to better estimate how long the medicine needs to be taken. Do not stop taking it without telling your doctor. It needs to be taken as long as it is effective and you can tolerate it.

Are there any food restrictions while I’m taking Pazoci 400 Tablet?

Yes, it is best to avoid grapefruit and grapefruit juice while on Pazoci 400 Tablet, as it may affect how the medicine works in your body. Ask your doctor about any additional foods you should avoid.

How long I have to take Pazoci 400 Tablet?

What is the most important information I need to know about Pazoci 400 Tablet?

Pazoci 400 Tablet may cause severe or life-threatening liver damage. Inform your doctor if you have or had liver disease. If you experience any of the following symptoms such as discoloration of the skin or eyes (yellowing), dark urine, extreme tiredness, nausea, vomiting, loss of appetite, pain in the upper right part of the stomach, or unusual bleeding or bruising, call your doctor immediately. Your doctor may ask you to take some lab tests before you start taking Votrient. After you start taking Votrient, you may need to take those lab tests at weeks 3, 5, 7 and 9 and then at months 3 and 4. Your doctor may also prescribe additional tests if necessary. Periodic testing should then continue after 4 months.

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Related lab tests

Complete Blood Count

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1072-73.
Pazopanib. Research Triangle Park, North Carolina: GlaxoSmithKline; 2009 [revised Apr. 2012]. [Accessed 24 Jan. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:

Marketer details

Name: Cipla Ltd

Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.