Nexzine 500mg Tablet is used for the management of angina (heart-related chest pain). It helps to prevent new attacks of angina but does not stop an acute attack, once started. It relieves chest pain by making the heart work more efficiently.

It is an anti-anginal medicine.

Uses of Nexzine Tablet

Treatment of Angina (heart-related chest pain)

Benefits of Nexzine Tablet

In Treatment of Angina (heart-related chest pain)

Nexzine 500mg Tablet reduces the oxygen requirement of the heart and relaxes the heart muscles. It makes sure that your heart is able to perform its functions in the amount of oxygen supply available without causing stress on heart muscles. This makes it less likely that you will suffer chest pain caused by angina. This medicine can help increase your ability to exercise and go about your daily life more easily by reducing the frequency of angina attacks. You should take it regularly and as long as it is prescribed for it to work effectively.

Side effects of Nexzine Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nexzine

Nausea
Vomiting
Headache
Dizziness
Constipation
Weakness

How to use Nexzine Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nexzine 500mg Tablet is to be taken with food.

How Nexzine Tablet works

Nexzine 500mg Tablet is an anti-anginal medication. It works by decreasing the oxygen requirement of the heart by relaxing heart muscle.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Nexzine 500mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Nexzine 500mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Nexzine 500mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Nexzine 500mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

CAUTION

Nexzine 500mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Nexzine 500mg Tablet may be needed. Please consult your doctor.
Use of Nexzine 500mg Tablet is not recommended in patients with severe kidney disease.

Liver

CAUTION

Nexzine 500mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Nexzine 500mg Tablet may be needed. Please consult your doctor.
Use of Nexzine 500mg Tablet is not recommended in patients with moderate to severe liver disease.

What if you forget to take Nexzine Tablet?

If you miss a dose of Nexzine 500mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Nexzine 500mg Tablet

₹13.0/Tablet

Ranoget 500mg Tablet

Mits Healthcare Pvt Ltd

₹14.5/tablet

12% costlier

Ranolite 500mg Tablet

Daxia Healthcare

₹9.5/tablet

27% cheaper

Razocard 500mg Tablet

Leeford Healthcare Ltd

₹12.5/tablet

4% cheaper

Ranoace 500mg Tablet

Maksun Biotech Pvt Ltd

₹14/tablet

8% costlier

Ranoven 500mg Tablet

Biovenice Criticure

₹13.5/tablet

4% costlier

View all substitutes

Quick tips

It should be taken with food to avoid stomach upset.
It improves HbA1c and blood sugar levels in diabetes patients.
It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Notify your doctor if you are taking any other medications along with Nexzine 500mg Tablet
It may produce changes in the ECG (QTc interval prolongation). It is recommended to get an ECG done within 1 to 2 weeks of starting the medication.

Fact Box

Chemical Class

Acetanilide & piperazine derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Late Sodium channel blocker- angina

Patient concerns

What is heart attack? When heart attack coming?

Dr. Nabajit Talukdar

Interventional Cardiology

Related to chest pain angina commonly

Chest pain headache vetrigo Angina pain

Dr. Nabajit Talukdar

Interventional Cardiology

Get echo n ECG done

FAQs

What are the serious side effects of Nexzine 500mg Tablet?

Nexzine 500mg Tablet may cause changes in the electrical activity of the heart which is known as QT prolongation. Your doctor may get regular tests done to check the electrical activity of your heart. Tell your doctor right away if you feel faint, lightheaded or if your heart starts beating irregularly or fast, as these may be symptoms of QT prolongation. Nexzine 500mg Tablet may also cause kidney failure in patients who already have kidney problems. Therefore, your doctor may need to do tests to check how your kidneys are working.

I started taking Nexzine 500mg Tablet about a week ago. Now I have noticed that my urine has become very dark though I am taking plenty of fluids. Is there anything to worry about?

Urine discoloration could be because of Nexzine 500mg Tablet. You need not worry if you do not have any other symptoms. However, if it still bothers you, you can talk to your doctor who will advise you further.

In case I accidentally take an excess of Nexzine 500mg Tablet, what will happen?

Excess of Nexzine 500mg Tablet can cause nausea, vomiting, lightheadedness, double vision, tiredness, severe tremor, confusion, hallucinations, difficulty in speaking and walking and you can even faint. If you have taken an excess of Nexzine 500mg Tablet by mistake, call your doctor right away or seek emergency medical care in a nearby hospital.

Is it safe to take Nexzine 500mg Tablet if I am already taking metoprolol?

Yes, it is safe to take the Nexzine 500mg Tablet and Metoprolol together. Nexzine 500mg Tablet has minimal effect on blood pressure in patients with angina.

I am a diabetic and am taking metformin. My doctor has prescribed Nexzine 500mg Tablet, is it safe to take both together?

If you are taking metformin along with Nexzine 500mg Tablet, you have to be careful since Nexzine 500mg Tablet may increase the levels of metformin in the body which can lead to metformin toxicity. Talk to your doctor who will modify the dose of metformin.

I have been taking simvastatin to keep my cholesterol levels in check. Can I take Nexzine 500mg Tablet with it?

It is recommended not to take simvastatin and Nexzine 500mg Tablet together because it may cause simvastatin toxicity which may lead to symptoms like muscle weakness and soreness, fatigue, decreased urination, etc. Let your doctor know that you are already taking simvastatin. If it is still necessary to take, then take it exactly as advised by the doctor.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Opie LH, Horowitz JD. Nitrates and Newer Antianginals β-Blocking Agents. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 56
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1200.
Ranolazine. Wooburn Green, Buckinghamshire: A. Menarini Farmaceutica Internazionale SRL; 2008 [revised 22 Nov. 2018]. [Accessed 25 Jan. 2019] (online) Available from:
Ranolazine. Foster City, California: Gilead Sciences, Inc.; 2013. [Accessed 20 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Ranolazine Sustained Release Tablets [Package Insert]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2019. [Accessed 25 Jul. 2023] (online) Available from:

Marketer details

Name: Nexkem Pharmaceuticals Pvt Ltd

Address: SCF-1009,2nd Floor, Motor Market, Manimajra Chandigarh, Chandigarh 160101 India.

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.