Combinib 250mg Tablet is used in the treatment of breast cancer. It works by stopping or slowing down the growth of cancer cells. It is either used alone or in combination with some other medicine to cure advanced-stage breast cancer.

Combinib 250mg Tablet should be taken on an empty stomach or an hour before or 2 hours after a meal. The dose and duration vary according to the severity of your condition and your response to treatment. Take it exactly as prescribed to avoid serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, headache, back pain, and breathing difficulty. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. You may be asked for regular monitoring of blood pressure while taking this medicine. Inform your doctor if you notice a severe headache, confusion, problems with your eyesight, nausea, or vomiting. Your doctor may check your liver function before, during, and after treatment with this medicine.

Before taking Combinib 250mg Tablet, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are taking. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Uses of Combinib Tablet

Breast cancer

Benefits of Combinib Tablet

In Breast cancer

Combinib 250mg Tablet helps to treat breast cancer and it may be used alone or in combination with other medicines or treatment modalities like chemotherapy. It relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipples or changes in the shape or texture of the breast. Combinib 250mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Discuss with your doctor if any of the side effects bother you.

Side effects of Combinib Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Combinib

Abdominal pain
Back pain
Breathing problems
Constipation
Cough
Diarrhea
Fatigue
Headache
Hot flashes
Increased bilirubin in the blood
Insomnia (difficulty in sleeping)
Joint pain
Liver damage
Loss of appetite
Mucosal inflammation
Nausea
Pain in extremities
Rash
Stomatitis (Inflammation of the mouth)
Vomiting
Weakness
Weight gain

How to use Combinib Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combinib 250mg Tablet is to be taken empty stomach.

How Combinib Tablet works

Combinib 250mg Tablet is an anti-cancer medication. It works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which are responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Combinib 250mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Combinib 250mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Combinib 250mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Combinib 250mg Tablet may cause side effects which could affect your ability to drive.

Kidney

CAUTION

Combinib 250mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Combinib 250mg Tablet may be needed. Please consult your doctor.
Limited information is available on the use of Combinib 250mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Liver

CAUTION

Combinib 250mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Combinib 250mg Tablet may be needed. Please consult your doctor.
Limited information is available on the use of this medicine in patients with the severe liver disease.

What if you forget to take Combinib Tablet?

If you miss a dose of Combinib 250mg Tablet, consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Combinib 250mg Tablet

₹212.5/Tablet

Tykerb 250mg Tablet

Glaxo SmithKline Pharmaceuticals Ltd

₹445/tablet

109% costlier

Herduo Tablet

Natco Pharma Ltd

₹199.33/tablet

6% cheaper

Abnib 250mg Tablet

Abbott

₹280.13/tablet

32% costlier

Libset Tablet

Intas Pharmaceuticals Ltd

₹199.83/tablet

6% cheaper

Lapahope 250mg Tablet

Glenmark Pharmaceuticals Ltd

₹190.67/tablet

10% cheaper

View all substitutes

Quick tips

It should be taken 1 hour before or 2 hours after the meal, preferably at the same time every day.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.

Fact Box

Chemical Class

Quinazolinamines Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine kinase inhibitors

Patient concerns

If any symtom of brest cancer if have whats the cure

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

First is confirmation of breast cancerChance of cure depends on stage of cancer

BREAST CANCER , PET REPORT SAYS INFECTION IN SKELETON.

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Metastatic breast cancer, send me previous treatment details

FAQs

Is Combinib 250mg Tablet a chemotherapy medicine?

No, this is a targeted drug that belongs to a class of anti-cancer medicines. They are more specific than chemotherapy in their mechanisms of action. Combinib 250mg Tablet belongs to the tyrosine kinase inhibitors group of medicines. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

Can Combinib 250mg Tablet be given in combination with other anti-cancer drug?

Yes, Combinib 250mg Tablet can be used with other anti-cancer drugs. Generally, it is used in combination with capecitabine to treat advanced breast cancer in patients who have already been treated with chemotherapy. Combinib 250mg Tablet is also used with letrozole to treat breast cancer in post-menopausal women.

How should I take Combinib 250mg Tablet?

You should take Combinib 250mg Tablet exactly as advised by your doctor. Swallow Combinib 250mg Tablet tablets whole with a glass of water, at the same time each day. You must take Combinib 250mg Tablet 1 hour before or 1 hour after meals and at the same time concerning food each day (e.g., you could always take your tablet one hour before breakfast).

Does Combinib 250mg Tablet have any effect on liver?

Combinib 250mg Tablet may cause liver damage which can be severe or life-threatening. Liver damage can occur as soon as several days or as late as several months after the start of treatment with Combinib 250mg Tablet. Inform your doctor if you have or had liver disease. If you experience any of the symptoms such as itching, change in color of the skin or eyes (yellowing), discoloration of urine, pain in the upper right part of the stomach, unusual bleeding or bruising, or pale or dark stools, call your doctor immediately.

How should I manage diarrhea while taking Combinib 250mg Tablet?

If you suffer from diarrhea while taking Combinib 250mg Tablet, you should drink plenty of fluids (8 to 10 glasses a day) such as water, sports drinks, or other clear liquids. You should eat low-fat, high protein foods instead of fatty or spicy foods. Eating cooked vegetables instead of raw vegetables and removing the skin from fruits before eating can also be helpful. Try to avoid milk and milk products (including ice cream) and herbal supplements (some may cause diarrhoea). Inform the doctor, if the condition persists, who may interrupt the treatment depending on the severity of diarrhea.

How can I take care of my skin while on Combinib 250mg Tablet?

Your doctor will check your skin before and during the treatment. If you have sensitive skin, use a soap-free cleanser and beauty products that are fragrance-free and hypoallergenic. It is also advised that you use sunscreen with an SPF (Sun Protection Factor) of 30 or higher. Inform your doctor immediately if you get a rash.

What tests will the doctor advise before starting Combinib 250mg Tablet?

You may need extra tests to check that your heart and liver are working properly. Combinib 250mg Tablet may change the way your heart beats and pumps blood through your body. Your doctor will monitor you carefully to see whether Combinib 250mg Tablet has affected your heart. Along with that, your doctor will get your liver function investigated. Based on the results of these tests, the doctor will decide whether dose adjustment or discontinuation of treatment is required.

How long after Combinib 250mg Tablet can I plan pregnancy?

Use an effective method of contraception to avoid pregnancy while you are taking Combinib 250mg Tablet and continue for at least 1 week after the last dose. Inform your doctor if you become pregnant, who will decide whether to stop or continue treatment.

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Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

Related ayurvedic ingredients

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1737-38.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 779-80.
Lapatinib ditosylate monohydrate. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 2008 [revised 13 Dec. 2018]. [Accessed 23 Jan. 2019] (online) Available from:
Lapatinib. Research Triangle Park, North Carolina: GlaxoSmithKline; 2007 [revised Mar. 2015]. [Accessed 26 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Lapatinib. [Updated 2019 Jan 7]. [Accessed 18 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:

Marketer details

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Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.