Dengue Fever Antigen NS1, IgG & IgM
Understanding Dengue Fever Antigen NS1, IgG & IgM
What is Dengue Fever Antigen NS1, IgG & IgM?
Dengue Antigen NS1, IgG and IgM test detects the non-structural protein component (NS1) of the dengue virus and the antibodies (IgG & IgM) produced by the body in response to the infection. NS1 and IgM is secreted into the blood during dengue infection and are detectable within 3-4 days of illness. Therefore this test helps in early diagnosis and treatment of dengue infection. IgG antibodies appear after 14th day of infection and persist for life.
The initial symptoms which are commonly seen in dengue include sudden high fever, fatigue and flu-like symptoms.
If left untreated the infection may progress to a severe forms such as Dengue hemorrhagic fever or Dengue shock syndrome.
What is Dengue Fever Antigen NS1, IgG & IgM used for?
The Dengue Antigen NS1, IgG & IgM test is done in case there is high fever within 2 weeks of travel to an area where dengue outbreak is occurring or dengue fever is endemic.
Interpreting Dengue Fever Antigen NS1, IgG & IgM results
Interpretations
Result in index |
Remarks |
Negative (<0.9) |
No detectable dengue NS1 antigen. The result does not rule out dengue infection. An additional sample should be tested for IgG & IgM serology in 7-14 days.
|
Equivocal (0.9-1.1) |
Repeat sample after 1 week
|
Positive (>1.1) |
Presence of detectable dengue NS1 antigen. Dengue IgG & IgM serology assays should be performed on follow up samples after 5-7 days of onset of fever, to confirm dengue infection. |
Note: Recommended to do NS1 Antigen by ELISA in the first 5 days of fever. After 7-10 days of continuous fever, the recommended test is Dengue fever antibodies IgG & IgM by ELISA.
ANTIBODY DETECTED |
REMARKS |
IgM |
Primary Dengue |
IgM & IgG |
Late Primary / Early Secondary Dengue |
IgG |
Secondary / Past Dengue |