Palborest 125mg Tablet is used to treat patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative) which have spread to other organs. It is given together with hormonal anticancer therapies.

It is an anti cancer medicines

Uses of Palborest Tablet

Breast cancer

Benefits of Palborest Tablet

In Breast cancer

Palborest 125mg Tablet helps to treat breast cancer and it may be used alone or in combination with other medicines or treatment modalities like chemotherapy. It relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipples or changes in the shape or texture of the breast. Palborest 125mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Discuss with your doctor if any of the side effects bother you.

Side effects of Palborest Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Palborest

Decreased blood cells (red cells, white cells, and platelets)
Fatigue
Hair loss
Rash
Vomiting
Diarrhea
Nausea
Decreased appetite
Infection
Decreased white blood cell count
Stomatitis (Inflammation of the mouth)
Anemia (low number of red blood cells)
Weakness
Fever

How to use Palborest Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Palborest 125mg Tablet is to be taken with food.

How Palborest Tablet works

Palborest 125mg Tablet is an anti-cancer medication. Cyclin dependent kinase 4 and 6 (chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells. This medicine works by inhibiting cyclin dependent kinase 4 and 6, thus arrests the cancer cell cycle (cell growing process). It also targets the estrogen (hormone) receptor-positive breast cancer cells by disrupting the cell cycle.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Palborest 125mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Palborest 125mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Palborest 125mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Palborest 125mg Tablet may cause side effects which could affect your ability to drive.
It may cause fatigue in some people. If this happens, you should exercise caution when driving or using machines.

Kidney

SAFE IF PRESCRIBED

Palborest 125mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Palborest 125mg Tablet is recommended.

Liver

CAUTION

Palborest 125mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Palborest 125mg Tablet may be needed. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Palborest 125mg Tablet

₹257.14/Tablet

Palbace 125mg Tablet

Pfizer Ltd

₹4523.81/tablet

1659% costlier

Quick tips

Take it with food, preferably at the same time every day.
If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed dose
Use effective contraception method to prevent pregnancy while taking this medicine.
It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Do not stop taking the medication without talking to your doctor first.

Fact Box

Chemical Class

Pyridinylpiperazines

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Cyclin-Dependent Kinase Inhibitor

Patient concerns

If any symtom of brest cancer if have whats the cure

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

First is confirmation of breast cancerChance of cure depends on stage of cancer

BREAST CANCER , PET REPORT SAYS INFECTION IN SKELETON.

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Metastatic breast cancer, send me previous treatment details

FAQs

What kind of medicine is Palborest 125mg Tablet?

Palborest 125mg Tablet is an anti-cancer medicine. Palborest 125mg Tablet blocks proteins known as cyclin-dependent kinase inhibitors. Blocking these proteins can slow down the growth of cancer cells and delay the progression of the cancer.

How long do I have to take Palborest 125mg Tablet?

The duration of treatment varies from person to person. Your doctor will decide the number of cycles you need to receive based on your condition, response to treatment and your tolerance to side effects. Your doctor may decrease your dose or stop your treatment temporarily or permanently if you experience certain side effects.

Are the side effects of Palborest 125mg Tablet irreversible?

No, most of the side effects are reversible and disappear when the medicine is stopped. Neutropenia is a well-recognized adverse effect of Palborest 125mg Tablet in which the number of your white blood cells get reduced and your immune system gets weakened. As a result, you may be at greater risk of getting an infection while you are taking Palborest 125mg Tablet. However, this side effect disappears rapidly once you stop taking the medicine.

Does treatment with Palborest 125mg Tablet require monitoring of blood counts?

Yes, blood tests are important since this medicine can lower your blood counts. The regular blood tests check the effect of Palborest 125mg Tablet on your blood cells (white blood cells, red blood cells, and platelets). These tests should be done at the beginning of each chemotherapy cycle, on the 15th day of the first 2 cycles, and as clinically indicated.

How should I take Palborest 125mg Tablet?

Generally, Palborest 125mg Tablet is taken once daily for 21 consecutive days followed by 7 days off treatment to add up a complete cycle of 28 days. Take this medicine with food and at the same time each day. Swallow the whole capsules. Do not open, chew, or crush them. Do not take the capsules that are broken or cracked. If you vomit after taking Palborest 125mg Tablet, do not take another dose and continue your regular dosing schedule.

Do I need to use birth control method while using Palborest 125mg Tablet?

Women of childbearing potential who are receiving Palborest 125mg Tablet and their partners should use adequate contraceptive methods (e.g. double-barrier contraception such as condom and diaphragm). These methods should be used during therapy and for at least 3 weeks after completing therapy for females. Men who are on Palborest 125mg Tablet therapy should use birth control methods for at least 14 weeks after completing the therapy.

Does Palborest 125mg Tablet affect fertility?

Male fertility may be affected during treatment with Palborest 125mg Tablet. Thus, men may consider sperm preservation prior to beginning therapy with Palborest 125mg Tablet.

What are the serious side effects of Palborest 125mg Tablet?

The serious side effects of Palborest 125mg Tablet include shortness of breath, dizziness, weakness, unusual bleeding or bruising or nosebleeds. It may also cause fever, chills or signs of infection and fast, irregular or pounding heartbeat. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Palbociclib. New York, New York: Pfizer Labs; 2015 [revised 31 Mar. 2017]. [Accessed 25 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:

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Address: MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA

Country of origin: India
Expires on or after: February, 2025

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