Denu Injection is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.

is used in the treatment osteoarthritis

Uses of Denu Injection

Osteoporosis

Benefits of Denu Injection

In Osteoporosis

Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. It often occurs in women after menopause. This condition can be treated with bone-strengthening medicines. Denu Injection slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. The injection is given by a doctor or nurse and should not be self-administered.
You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.

Side effects of Denu Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Denu

Musculoskeletal (bone, muscle or joint) pain
Pain in extremities
Nerve pain
Constipation
Rash
Urinary tract infection

How to use Denu Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Denu Injection. Please consult your doctor.

Pregnancy

UNSAFE

Denu Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

SAFE IF PRESCRIBED

Denu Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving

SAFE

Denu Injection does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Denu Injection is safe to use in patients with kidney disease. No dose adjustment of Denu Injection is recommended.

Liver

SAFE IF PRESCRIBED

Denu Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Denu Injection may not be needed in these patients. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Denu Injection

₹20000.0/Injection

Odensomab 60mg Injection

Lupin Ltd

₹19600/injection

2% cheaper

Denorange Injection

Biorange Biologicals Private Limited

₹21000/injection

5% costlier

Denbri Injection

RPG Life Sciences Ltd

₹23500/injection

18% costlier

Denaxa Injection

Abbott

₹17000/injection

15% cheaper

Quick tips

Denu Injection is a medication used to treat thinning of the bones (called osteoporosis).
Take calcium and vitamin D to help build your bones when taking Denu Injection.
Do not take if you are pregnant or plan to become pregnant.
May cause a rare problem of the jaw (osteonecrosis), mostly seen after a dental procedure. Tell your doctor if you develop sudden jaw pain.
Denu Injection may also increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
Tell your doctor if you develop a rash while taking Denu Injection.

Fact Box

Chemical Class

Monoclonal antibody (mAb)

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Bone resorption inhibitors- Monoclonal antibodies

Patient concerns

Teriparatide is this injection advisable?

Dr. Akshat Goel

Orthopaedics

Yes, it's good in Osteoporosis

Details About osteoporosis treatment

Dr. Akshat Goel

Orthopaedics

Take Calcium and Vitamin-D3 supplements

FAQs

How long can you stay on Denu Injection?

There is no optimal duration of treatment of osteoporosis with Denu Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denu Injection. Depending on this, the duration of taking Denu Injection is decided.

Does Denu Injection cause hair loss?

Yes, hair loss is a common side effect of Denu Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.

Is Denu Injection a chemotherapy drug?

Denu Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denu Injection makes the bones stronger and less likely to break.

How is Denu Injection given and how often?

Denu Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denu Injection.

Can Denu Injection be taken during pregnancy?

No, pregnant women should not take Denu Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Denu Injection if you can become pregnant.

How should Denu Injection be stored?

Denu Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.

Does Denu Injection cause osteonecrosis of the jaw?

Osteonecrosis is a rare side effect of Denu Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denu Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
Drugs.com. Denosumab. [Accessed 02 Apr. 2019] (online) Available from:
Denosumab. Milton Road, Cambridge: Amgen Ltd.; 2010 [revised Jun. 2018]. [Accessed 02 Apr. 2019] (online) Available from:

Marketer details

Name: Alkem Laboratories Ltd

Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.