Fever Package Advanced (includes Dengue, Malaria & Typhoid Tests)

The Widal test measures the titres of antibody against the bacteria which cause Enteric fever.

Typhoid and paratyphoid fever are generally acquired when you consume food or water, contaminated by feces of an acutely infected or convalescent person (recovering from disease) or a chronic, asymptomatic carrier. The incubation period (the time interval between exposure to an infection and the appearance of the first symptoms) of Enteric fever is 6-30 days. Paratyphoid fever is similar but often less severe than typhoid fever.

Widal test is an agglutination test to detect antibodies (agglutinins) in a blood sample against two antigens (O & H) of bacteria, Salmonella enterica. Agglutination refers to the visible clumping of particles when a particulate antigen combines with its antibody in the presence of optimum conditions for antigen-antibody reaction. When this test is performed on a slide, it is called Slide agglutination and when it is carried out in a test tube,  it is called Tube agglutination. Widal test by Tube agglutination is recommended over Slide agglutination method. The antigens used in the test are “H” and “O” antigens of Salmonella Typhi and “H” antigen of S. Paratyphi.

Widal test should only be performed after the first week. The reason being the antibody against “O” and “H” antigens of Salmonella start appearing in serum at the end of the first week of fever. It is preferable to test two blood samples at an interval of 7 to 10 days to demonstrate rising antibody titres.

A Typhidot, IgG & IgM test is an important diagnostic tool to diagnose typhoid fever. This test usually shows the infection within 2-3 days and detects IgM and IgG antibodies, illustrating a recent and a past infection respectively. When Salmonella typhi, the causative bacteria from typhoid, enters the body, your immune system, as a response, releases two types of antibodies (specific proteins), IgM and IgG, against the outer membrane protein of Salmonella typhi.

The Typhidot, IgG & IgM test is a qualitative rapid immunochromatographic test for the detection of Typhoid IgG and IgM antibodies. 

The Malarial Falciparum and Vivax antigen test is a rapid diagnostic test which detects the presence of malarial antigen in the blood sample. Malaria is an infectious disease which is caused by a species of Plasmodium parasite. It is transmitted by the bite of an infected mosquito (female anopheles). The species which cause infections in humans include Plasmodium Vivax, Plasmodium malariae, Plasmodium ovale, and Plasmodium falciparum. 

This malarial infection may rarely pass from a woman to her baby during pregnancy, labor, or delivery. Also, the chances of the spread of infection are very low through blood transfusion, sharing of contaminated needles or syringes, and organ transplant. 

When an infected mosquito bites a person, the parasites enter into the blood and travel to the liver. After a person is infected it takes about 7-30 days for the eggs to mature. The parasites enter the red blood cells of a person where they multiply inside these cells. These cells burst within 48 to 72 hours which leads to the occurrence of symptoms of malaria. 

The disease can relapse in case the infection is caused by P. vivax and P. ovale species. This is because these parasites can remain inoperative in the liver before they enter again into the blood and may take up to months and even years for the symptoms to appear.

If the malarial infection is not treated, it can cause severe illness and even death. The species likely to cause life-threatening disease is P. falciparum.