Macbutin Tablet is an antibiotic, used in the treatment of tuberculosis with HIV (human immunodeficiency virus) infection. It helps to fight germs (bacteria) called mycobacteria, which cannot be destroyed by other antibiotics in people who have a weaker immunity.

It is an antibiotic.

Uses of Macbutin Tablet

Tuberculosis with HIV infection

Benefits of Macbutin Tablet

In Tuberculosis with HIV infection

Macbutin Tablet helps treat Mycobacterium avium complex disease (MAC; a bacterial infection that may cause serious symptoms) in patients with human immunodeficiency virus (HIV) infection. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Macbutin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Macbutin

Nausea
Rash
Fever
Anemia (low number of red blood cells)
Decreased white blood cell count

How to use Macbutin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macbutin Tablet is to be taken empty stomach.
Avoid Macbutin Tablet with acidic food and beverages such as sugar, certain dairy products, fish, processed foods, fresh meats and processed meats,sodas and other sweetened beverages.

How Macbutin Tablet works

Macbutin Tablet works by inhibiting an enzyme DNA-dependent RNA polymerase in bacteria, leading to the suppression of RNA synthesis that is required for survival and this leads to cell death of infection-causing bacteria. This helps treat Mycobacterium avium complex disease (tuberculosis) in patients with human immunodeficiency virus (HIV) infection.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Macbutin Tablet. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Macbutin Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Macbutin Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving

SAFE

Macbutin Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Macbutin Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Macbutin Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Macbutin Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Macbutin Tablet may be needed. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Macbutin Tablet is used to treat tuberculosis in patients with HIV.
Seek immediate medical attention if you develop sudden wheeziness, difficulty in breathing, pain in the chest, swelling of eyelids, face, or lips, rash or itching.
Taking Macbutin Tablet may change the color of your urine to red/orange. You may also experience coloring of the skin and other body fluids and also of soft contact lenses.
You may be regularly monitored with blood tests and chest X-rays to check that you do not have active tuberculosis or any other mycobacterial disease.
You may also undergo regular eye examinations while using Macbutin Tablet.
Use non-hormonal birth control techniques (condom, diaphragm with spermicide) to prevent pregnancy, as Macbutin Tablet can make birth control pills less effective.

Fact Box

Chemical Class

Macrolactams

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

RNA polymerase inhibitors- Rifamycins

Patient concerns

hello, one of my frnd suffering with hiv infection from last 2yrs her cd4 is more than 470 and viral load is zero undetectable now she is using art medicines i have doubt that can we have to use art medicine in the whole life or can we stop it once we get viral load zero

Dr. Atula Gupta

Dermatology

You still need to be on ART even if the viral load is undetectable

i have unprotected sex with my friend. Can I take any drugs now to prevent any STD/HIV infection

Dr. Shyam Gupta

Obstetrics and Gynaecology

Hello PATIENT to 1mg. There is some medicine for prophylactic but you need to see physician for prescription and better you check HIV status of both partner

He is suffering from Lungs problem Actually he's a smoker & Diabetic. Before 2 week his left lung was collapsed and left lung got shrink . Doctor had done chest tube & after he got pneumonitis doctor has starting Antibiotic(Tazomac 4.5gm TDS +linezolid 600 BD) with Nebulizer of Foracort & Duolin + Doxyphillin 400 tab.TDS Doctor gave this treatment for 10 day after . After this CBC was Normal. but chest tube Bag was bubbling . Doctor remove chest tube becoz the Bag was looking normal But after three Days lungs collapse and Again Doctor Is doing same process . I am attaching report (CECT, Sputum complete Examination , CBC ,Blood culture etc.) with this. Please guide me the Better way to improve. What shoul we do.

Dr. Sunil Sekhri

Diabetology

Patient has Pneumothorax with pleural effusion and mild pericardial effusion. there are cavitation in lungs. cause could be Tuberculosis, Malignancy, fungal infection most likely. You need to consult a Doctor specialising in respiratory diseases.

User feedback

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Related lab tests

HIV 1 - Quantitative (Viral Load)

HIV 1 And 2 Antibody - ELISA

Mycobacterium Tuberculosis DNA PCR - Qualitative

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1550-554.
Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 829.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1212-13.
Rifabutin. Sandwich, Kent: Pfizer Limited; 2003 [revised Dec. 2015]. [Accessed 25 Jan. 2019] (online) Available from:
Medscape. Rifabutin. [Accessed 01 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:

Marketer details

Name: Macleods Pharmaceuticals Pvt Ltd

Address: Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Country of origin: India

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Macbutin Tablet

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